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Milk Thistle is a herbaceous annual or biennial plant with a dense-prickly flower head and reddish-purple tubular flowers. It is native to the Mediterranean region and has been naturalized in Central Europe, North and South America, and Southern Australia. Milk Thistle has an extensive history of use as an edible plant. In the 1st century AD, Pliny the Elder reported its use for supporting liver health. Theophrastus (IV century BC) and Dioscorides (1st century AD) also wrote of its value. The English herbalist, Nicholas Culpeper (1650) claimed it was effective for supporting the normal functioning of the liver. At the turn of the 20th century, Eclectic physicians also used Milk Thistle to support healthy liver function. Much of the modern day research has been conducted in Germany where it is an approved herb in The German Commission E Monographs.