Melatonine cas 73-31-4

Product Name: Melatonine
Synonyms: Melatonin (AS);Melatonine,N-(2-(5-Methoxyindol-3-yl)ethyl)acetaMide;MELATONINE FOR SYNTHESIS 1 G;MELATONINE FOR SYNTHESIS 5 G;Melatonin solution ;N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE;N-(2-(5-methoxyindol-3-yl)ethyl)acetamide;MLT
CAS: 73-31-4
MF: C13H16N2O2
MW: 232.28
EINECS: 200-797-7
Product Categories: Inhibitors;bulk drug material;Heterocyclic Series;Heterocycles series;Indoles;Melatonin receptor;Tryptamines;Nutritional Supplements;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Heterocycles;Melatonins;Vitamin series;Alkaloid;Bioactive Small Molecules;Building Blocks;C13 to C27;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Heterocyclic Building Blocks;M;Neurobiology;Neuroscience;Nutrition Research;Pharmacologicals;Phytochemicals by Chemical Classification;Herb extract;Other APIs;Melatonex;inhibitor;Cosmetics;cosmetics materials
Mol File: 73-31-4.mol
description Melatonin is a hormone secreted by the pineal gland, and its chemical structure was 5-methoxy-N-acetyl tryptamine, the physiological function of inhibiting gonad, thyroid, adrenal gland, parathyroid gland and pituitary function, inhibit precocious puberty, reduce pituitary Melanotropin secretion; and has a central nervous system function, can improve the convulsion the threshold, cause drowsiness. When pinealectomy after the animal experiment showed hyperplasia of the glands, weight increase, especially sex and sexual organs of immature rats early, pituitary secretion of LH and FSH increased, increasing secretion of thyroid and adrenal cortex hormone melatonin. More reduced pituitary MSH and whiten the skin of this role. Effects on the central nervous system, in the human EEG showed slow rhythm, increased seizure threshold, sleepiness, but does not affect their behavior and personality, of temporal lobe epilepsy and Ba Jinsen disease can reduce the motor nerve Abnormal EEG changes.
Chemical properties Melatonin is a slightly off-white, odourless crystalline powder. It is very slightly soluble in water and in dilute hydrochloric acid.
Melatonin
Melatonin is a small molecule, a derivative of the amino acid tryptophan, N-acetyl-5 methoxytryptamine. It is a potent hormone with well-recognized activities and the potential to influence many bodily functions. It is produced by the pineal gland in the brain and is secreted when the body recognizes darkness. Melatonin has intense effects on the timing of the sleep/awake cycle, regulating the circadian rhythms of several biological functions. This is its most studied biological activity. Melatonin, as a multifunctional hormone, appears to regulate or modulate other functions in humans through the activation of its receptors and works as a strong antioxidant that protects the DNA. Melatonin’s antioxidant activity may reduce Parkinson’s disease development, prevent cardiac arrhythmia, and, in animals, promote longevity.
Mechanism of action Melatonin is a naturally occurring hormone produced by the pineal gland and is structurally related to serotonin. Physiologically, melatonin secretion increases soon after the onset of darkness, peaks at 2-4 am and diminishes during the second half of the night. Melatonin is associated with the control of circadian rhythms and entrainment to the light-dark cycle. It is also associated with a hypnotic effect and increased propensity for sleep.
The activity of melatonin at the MT1 MT2 receptors is believed to contribute to its sleep-promoting properties via their distinct actions on the circadian clock. The MT1 receptors are thought to inhibit neuronal firing, while the MT2 receptors have been implicated in the phase-shifting response.
Uses 1. Melatonin can be used as medicine health care products, so as to enhance people’s immune function, preventing aging and back to youth. What’s more, it is also a kind of natural “sleeping pill”.
2. Melatonin is a kind of hormone secreted by pineal body of pituitary gland in the body. The amount of melatonin has something to do with light. The weaker the light is, the more the melatonin is, whereas the less. In addition, it is helpful to one’s sleep.
3. Biochemical research.
Biological Activity Melatonin is a naturally compound found in animals, plants, and microbes. It is a hormone secreted by the pineal gland. Melatonin can directly neutralize a number of ROS, stimulate several antioxidant enzymes, reduce UV-induced erythema, modulate the expression of apoptosis and alleviate sleep disturbances. The mechanism of biological effects is via activation of melatonin receptors or protection of nuclear and mitochondrial DNA.
In the skin, melatonin scavenges and inactivates free radicals arising from UV irradiation. Melatonin represents a substance which protects cells from UVA and UVB action in vitro and in vivo experiments. Preincubation with melatonin can lead to the normalization of the decreased UV-induced mitochondrial membrane potential. Such effects are followed by suppression of the activation of mitochondrial pathway-related initiator caspase 9 (casp-9), but not of death receptor-dependent casp-8. Melatonin also down-regulates casp-3/casp-7 and reduces PARP activation (Fischer et al,. 2008).