H3K4ME2

Synthesized histone H3 peptide corresponding to residues within 1-135 of human histone H3 with dimethylation K4 modification.

SPECIFICATION OF H3K4ME2
CAT H3102
Product 
Name Histone H3-K4me2
Purity ≥95% by HPLC analysis
Appearance White powder
Usage Research use only
Storage Shipping at room temperature.
Upon delivery aliquot.
Stored at -20®C or -80®C.
Avoid freeze/thaw cycle.
Sequence ARTK(me2)QTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFKT DLRFQSSAVM ALQEACEAYL VGLFEDTNLC AIHAKRVTIM PKDIQLARRI RGERA

APPLICATION OF H3K4ME2
H3K4me2 is a modification thought to have a role in transcriptional memory. In CD4+ T lymphocytes, H3K4Me2 is present within gene bodies regulating cellular function, but not in those of housekeeping genes, which indicates that the modification has a role in refining the tissue-specificity of expressed genes. This type of cellular identity targeting is also noted in work with human and mouse spermatozoa; the H3K4Me2 modification marks genes that are relevant in spermatogenesis. Most effects of H3K4Me2 seem to be attributed to its transcriptional activation; however, recent work also indicates that it may also play an RNA-dependent regressive role, related to the GAL-1 promoter.

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