GALAXOLIDE Cas 1222-05-5

Product Name: GALAXOLIDE
Synonyms: ABBALIDE;1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA[G]-2-BENZOPYRAN;1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYL-CYCLOPENTA-GAMMA-2-BENZOPYRAN;1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta(g)-2-benzopyra;GALAXOLIDE;GALAXOLIDE 50;GALAXOLIDE 50 BB;GALAXOLIDE 50 IPM
CAS: 1222-05-5
MF: C18H26O
MW: 258.4
EINECS: 214-946-9
Product Categories: Aromatics;Detergents;Alphabetical Listings;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Flavors and Fragrances;G-H
Mol File: 1222-05-5.mol
GALAXOLIDE Structure
GALAXOLIDE Chemical Properties
Melting point 57-58®
Boiling point 304 ®C(lit.)
density 1.044 g/mL at 25 ®C(lit.)
refractive index n20/D 1.5215(lit.)
Fp >230 ®F
storage temp. Sealed in dry,Room Temperature
CAS DataBase Reference 1222-05-5(CAS DataBase Reference)
Chemical Properties Clear Colourless to Pale Yellow Oil
Chemical Properties 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]benzopyran is a viscous liquid with a musk-like odor. It is one of the most frequently used synthetic, artificial musk fragrances.The starting material for its synthesis is 1,1,2,3,3-pentamethylindane, which is prepared by cycloaddition of tert-amylene to α-methylstyrene. The pentamethylindane is hydroxyalkylated with propylene oxide in a Friedel–Crafts reaction using aluminum chloride as a catalyst (analogous to the synthesis of phenylethyl alcohol from benzene and ethylene oxide . Ring closure of the resulting 1,1,2,3,3-pentamethyl-5-(β-hydroxyisopropyl)indane is accomplished with paraformaldehyde and a lower aliphatic alcohol via the acetal or with paraformaldehyde and a carboxylic acid anhydride via the acylate.
The commercial product is diluted with solvents (e.g., diethyl phthalate, isopropyl myristate, benzyl benzoate) to make it less viscous. It is alkali-stable and does not discolor in light. Therefore, it is a popular ingredient of perfume compositions for soaps, detergents, and cosmetics and is used in large amounts.
Uses Galaxolide is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents.
Definition ChEBI: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.
Trade name Galaxolide¬ (IFF), Astromusk (Agan),Musk YingHai (YingHai).