Factory supply SR9009/Stenabolic CAS:1379686-30-2 with wholesale price

Biological activity of SR9009 (Stenabolic)

Biological activity in vitro
SR9009 dose-dependently increased SR9009 and its analog SR9011 in HEK293 cells expressing the chimeric Gal4 DNA-binding domain: REV-ERB ligand-binding domain alpha or beta and a Gal4-responsive luciferase reporter gene in a dose-dependent manner increased REV-ERB-dependent repressor activity. Furthermore, SR9009 was found to inhibit BMAL1 messenger RNA expression in HepG2 cells in a REV-ERB-α/β-dependent manner

Biological activity in vivo
The researchers found in mice that SR9009 caused a reduction in fat mass and blood lipids. In vivo, SR9009 inhibited the growth of malignant gliomas and improved their survival in mice without causing significant toxicity. SR9009 penetrates the blood-brain barrier and inhibits tumor growth in a xenograft model using patient-derived malignant glioma explants. Significantly improved survival in two different models of malignant glioma.

How SR9009 (Stenabolic) Work？

SR9009 (stenabolic) is an agonist of Rec-ERbA (Alpha), so SR9009 can enhance Rev-ErbA activity in our body. Rev-ErbA is a protein mainly found in muscle, skeletal muscle, fat and liver. The figure below is a molecular picture of REV-ErbA. SR9009 (stenabolic) works by stimulating the Rev-Erb protein that has an effect on circadian rhythms, fat storage cells, and glucose and lipid metabolism. By activating the Rev-ErbA protein, it can increase cellular mitochondria. Generation, let's see how SR9009 (stenabolic) works from the effects of SR9009 (stenabolic) on different tissues in the body?

1. Muscle tissue

SR9009 (Stenabolic) increases the number of mitochondria in muscles by increasing the activity of Rev-ErbA in human muscles, mitochondria are the "energy factories" of cells whose task is to convert the fats, carbohydrates and proteins we eat into usable ones energy. When muscle cells lose mitochondria, they become weak, especially after injury, whether it is injury or muscle damage caused by exercise, recovery will be particularly slow. An increase in cellular mitochondria in human muscle results in increased muscle strength and improved endurance, while increasing metabolic rate.

SR9009 showed a 50% increase in endurance during use due to increased mitochondrial numbers. SR9009 boosts metabolic activity and is known to simulate aerobic exercise without actually exercising, hence the name "Workout in a Bottle". It can promote fat loss. During use, SR9009 (Stenabolic) promotes the increase of mitochondria in muscles, which promotes the body to burn fat and increase endurance.

2. Liver tissue

Rev-ErbA organizes the production of new fat cells by binding liver fat cells, SR9009 (Stenabolic) enhances this effect, so this means that people on the SR9009 cycle will produce significantly fewer fat cells than those who do not take this compound, in essence Above all, it indirectly promotes fat loss in the liver because the body produces fewer fat cells.

3. Adipose tissue

SR9009 (Stenabolicbolic) can promote metabolic activity and simulate aerobic exercise to promote fat loss. Rev-ErbA also blocks genes that allow the body to store fat, and SR9009 (Stenabolicbolic) enhances this, reducing fat storage even with increased dietary intake.

Through the above understanding, SR9009 (Stenabolic) can promote the reduction of fat in human tissues, improve strength and improve endurance by enhancing the effect of Rev-ErbA.


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