FAT EMULSION EXCIPIENTS

In the field of medicine, fat emulsion injections like clevidipine lipid emulsion are frequently used as a submicroemulsion injection with lipid microspheres serving as the drug carrier. Meanwhile, egg yolks are a known source of lecithin, a phospholipid that is often utilized in the production of lipid emulsion injections like clevidipine.

FAT EMULSION EXCIPIENTS FOR SALE
Phospholipids (For Fat Emulsion)
> Egg yolk lecithin PL-100M
> Egg yolk lecithin PC-98T
> Soy Lecithin CS-80
Egg yolk lecithin is the only emulsifier with better safety profile. Its emulsification efficacy is a critical factor to the quality of lipid emulsions. Emulsification ability is an important basis for selecting egg yolk lecithin in the development of lipid emulsions.

Auxiliary Emulsifier (For Fat Emulsion)
> Oleic Acid
> Egg phosphatidylglycerol (for injection) EPG
> Sodium Oleate
The initial formula of injectable lipid emulsions uses soybean oil as the oil phase and egg yolk lecithin as the emulsifier to achieve good formulation stability and safety. With the development of injectable lipid emulsions, a variety of oils phase with different properties such as olive oil, MCT, fish oil, and drug-containing therapeutic emulsions are developed, which poses challenges to the formulation stability. In some cases, the use of single emulsifier cannot meet the quality requirements, so it is necessary to use oleic acid or sodium oleate as an auxiliary emulsifier.

Fat Emulsion Excipients Benefits
1. Intralipid emulsion of fat excipent egg yolk lecithin is used as emulsifier in nutritional and therapeutic injectable lipid emulsions (intralipid emulsion therapy), presenting excellent emulsifying properties and ability to enhance the emulsion stablity.

2. The egg yolk lecithin is soluble in soybean oil at 60®C, which is easy to process in preparation.

3. The egg yolk lecithin keeps the emulsion in a relatively stable particle size and pH, and prolongs the validity period of the emulsion.

4. Oleic acid can be used as co-emulsifier in lipid emulsions to improve the emulsification of lipids effect and enhance the stability of the emulsion.

FAT EMULSION EXCIPIENTS USES
01
Fat emulsion injection excipents egg yolk lecithin is the only emulsifier with better safety profile and it can be used for emulsion parenteral. Its emulsification efficacy is a critical determining factor to the quality of lipid emulsions.

02
Fat emulsion uses oleic acid as co-emulsifier in lipid emulsions to improve the emulsification effect and enhance the stability of the emulsion.

SELECTION OF FAT EMULSION EXCIPIENTS
Utilize excipients approved for parenteral use.

Select as less types and volumes of excipients as possible in injections,

like intralipid 20% 100ml or intralipid 10% 500ml, while meeting the requirement.

Utilize excipients which are commonly used in injections as much as possible,

for example, the clevidipine lipid emulsion excipient.

Now the fat emulsion injection price is reasonable, if you have needs, please contact us.

As a pharma excipients supplier, we can provide kinds of excipients in pharmaceutical formulations for sale, if you have needs, please contact us.