DEXAMETHASONE ACETATE RAW POWDER CAS NUMBER 1177-87-3

Dexamethasone Acetate is a glucocorticoid with anti-inflammatory properties. One possible mode of action of the anti-inflammatory properties has been documented by Dexamethasone Acetate inhibitiing upregulation of ICAM-1 (intercellular adhesion molecule-1) in cultured human mast cells. The compound also displays anti mitotic activity against chemically transformed mouse fibroblasts by halting mitosis from entering the S-phase. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.
References:
1. Fagot, D., et al. 1991. Endocrinology. 129: 1033-1041. PMID: 1906802
2. Roberts, C.P., et al. 1996. Am. J. Obstet. Gynecol. 175: 248-257. PMID: 8765239
3. Inamura, H., et al. 2001. Allergy. 56: 672-678. PMID: 11421927
4. Clark, J.A., et al. 2008. Mol. Psychiatry. 13: 498-506. PMID: 17622221
5. Wang, M.T., et al. 2010. Int J. Nanomedicine. 5: 487-497. PMID: 20957171

CAS No.1177-87-3
Chemical Name:Dexamethasone-17-acetate
SynonymsDEXAMETHASONE ACETATE;DEXAMETHASON ACETATE;DEXAMETHASONE 21-ACETATE;9-fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate;Dectan;Panasone;Dectancyl;NSC 39471;Decadronal;Decadron-la
CBNumber:CB9703269
Molecular Formula:C24H31FO6
Molecular Weight:434.5
MDL Number:MFCD00027407
MOL File:1177-87-3.mol

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