Cas 13463-41-7 Zinc pyrithione

Product Name: Zinc pyrithione
Synonyms: 1-HYDROXY-2-PYRIDINE THIONE, ZN SALT;1-HYDROXYPYRIDINE-2-THIONE ZINC;Pyrithione zincique;Bis[(1-oxylatopyridinium)-2-ylthio] zinc;Bis[(1-oxylatopyridinium-2-yl)thio]zinc;Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt;Bis(2-pyridylthio) Zinc 1,1'-Dioxide 1-Hydroxypyridine-2-thione Zinc Salt 2-Pyridinethiol 1-Oxide Zinc Salt Zinc Pyrithione;zincpolyanemine
CAS: 13463-41-7
MF: C10H8N2O2S2Zn
MW: 317.7
EINECS: 236-671-3
Product Categories: Classes of Metal Compounds;Transition Metal Compounds;Organometallics;Heterocyclic Compounds;Zn (Zinc) Compounds;1,2,4-Triazole,Triazoles ,Triazines;CYSTEX;personal care;Cosmetics shampoo anti danruff;Dye
Mol File: 13463-41-7.mol
Zinc pyrithione Structure
Zinc pyrithione Chemical Properties
Melting point approximate 240℃
density 1.782 g/cm3(Temp: 25 ®C)
storage temp. Sealed in dry,Room Temperature
Water Solubility Insoluble (<0.1 g/100 mL at 21 ºC)
Merck 14,7994
InChIKey OTPSWLRZXRHDNX-UHFFFAOYSA-L
CAS DataBase Reference 13463-41-7(CAS DataBase Reference)
EPA Substance Registry System Zinc pyrithione (13463-41-7)
Safety Information
Hazard Codes T+,N,T
Risk Statements 24/25-26-37/38-41-50/53-23-22
Safety Statements 26-28-36/37/39-45-61-60-39
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS ZH0950000
HazardClass 6.1(b)
PackingGroup III
HS Code 29333990
Hazardous Substances Data 13463-41-7(Hazardous Substances Data)
Toxicity LD50 oral in rat: 177mg/kg
MSDS Information
Provider Language
2-Pyridinethiol-1-oxide zinc salt English
SigmaAldrich English
Zinc pyrithione Usage And Synthesis
Product description Zinc pyrithione is the pyrithione complexes of zinc bromide, in the early 1930s, was already synthesized and used as a topical antifungal or antibacterial agent. At room temperature it is white to yellow crystalline powder. Slight characteristic odor. Insoluble in water. Solubility: water 15mg/kg; pH = 8 Water 35mg/kg; Ethanol 100mg/kg; polyethylene glycol (PEG400) 2000mg/kg. A pH optimum range of 4.5 to 9.5; mass fraction of 10% suspension pH3.6. Zinc pyrithione react with cationic and non-ionic surfactants forming insoluble precipitate, unstable in the light and oxidizer, when at higher temperatures ,it is not stable to acids and bases . It is not compatible with EDTA, non-ionic surfactants make it partially deactivated. When with the presence of heavy metals, chelation or anti-sequestration will occur, and these chelates are insoluble in water.
EEC and GB7916-87 provide that maximum allowable concentration of mass fraction of zinc pyrithione on cosmetics is 0.5%, only for cleaning after using products.General concentration 250~1000mg/kg (active), zinc pyrithione can be used in gels, creams, lotions, talcum powder and anti-dandruff shampoo, deodorant and also for disinfecting articles.
Uses Shampoo for dandruff,zinc pyrithione can inhibit Gram positive and negative bacteria and mold growth,Care hair Effectively , delay hair aging ,control white hair and hair loss generation. zinc pyrithion is also used as a cosmetic preservative, oil, paint biocide.
Zinc pyrithione has a strong killing power on fungi and bacteria so that it can effectively kill dandruff fungus,playing a role in dandruff .
Pharmaceutical Applications Zinc pyrithione is a regulator of keratinization, selenium sulfide has antimicrobial properties and ketoconazole is an antifungal agent (i.e.can provide the reduction of the lipophilic yeast Malassezia furfur).
Efficacy Zinc pyrithione shampoos (in concentrations between 1 to 2%) and shampoos with selenium sulide have been reported to be effective in the treatment of scalp psoriasis.However,their efficacy has not been substantiated by controlled studies.There is also some evidence that shampoos with antifungal agents (e.g.ketoconazole)can have a beneficial effect on scalp conditions. It should be noted, however, that the effectiveness of these shampoos is much smaller than these containing tars, corticosteroids or keratolytics.