2022 Best quality AICAR/Acadesine Powder for sale CAS:2627-69-2

What is AICAR?
AICAR, 5-aminoimidazole-4-formamide-1-β-d-furan ribofuranoside ( 5-aminoimidazole-4-carboxamide1-β-d-ribofuranoside ) , also called AICARiboside or Acadesine, AMP-activated protein kinase(AMPK) is an activator that permeates cell membranes.
AMPK is a key protein in metabolic regulation, which can regulate cell energy and control cell metabolism.
SARM AICAR is a recognized AMPK activator and plays an important role in the medical field. So, how does AICAR activate AMPK?

How does AICAR activate AMPK?
AMPK is a complex heterotrimeric structure, which consists of one catalytic subunit and two regulatory subunits. The α subunits (α1 and α2) are catalytic subunits, with a molecular weight of 63KD. β and γ subunits are regulatory subunits, β subunit has β1, β2 isoforms; γ subunit has γ1, γ2, γ3 isoforms. AMPK is widely present in eukaryotic cells, and AMPKα1 is mainly distributed in liver, kidney, heart, lung, brain and islet β-cells. Ampkα2 is mainly distributed in skeletal muscle, heart and liver. In terms of cell distribution, AMPKα1 and AMPKα2 are also different, AMPKα1 is mainly distributed in the cytoplasm, while AMPKα2 is mainly present in the nucleus.
AMPK activity is regulated by the energy change in the cell and is a monitor of the energy change in the cell, mainly regulated by the AMP/ATP ratio in the cell. Under normal conditions, the AMP/ATP ratio remains stable to maintain the basic metabolic energy requirements of the cell. When the cell is in a state of stress, such as ischemia, hypoxia, starvation, intracellular PH change, oxidative stress and increased creatine/phosphate ratio, the AMP/ATP ratio increases. Thus, AMPK is activated, which causes the activation or inhibition of downstream signaling molecules, reduces anabolic metabolism, promotes catabolic process, improves ATP generation, and restores the AMP/ATP ratio to normal and maintains stability.
AICAR is an adenosine analogue, which can be catalyzed by adenosine kinase to form its single nucleotide derivative ZMP in vivo or in cells. ZMP has an AMP-like effect, thereby causing the increase of AMP/ATP ratio and the activation of AMPK.

What effect does AICAR have on AMPK activation?
Studies have found that AMPK pathway inhibits tumor cell formation in normal tissues, and it has been proved to be toxic to most human tumor cell lines in vitro, which makes AMPK a new target for cancer treatment, and AICAR, which can activate AMPK, also has anti-tumor effect.
Based on the role of AMPKα1 in islet cells, AICAR activation of AMPK inhibits fat synthesis, thereby reducing fat content in the body from the source.
Based on the role of AMPKα2 in skeletal muscle, AICAR for bodybuilding, after activation of AMPK, contributes to muscle growth and thus is suitable for fitness.

AICAR for bodybuilding not only has a large audience in bodybuilder, but also has many other functions, such as:
Treatment of cancer
Mutations in cancer suppressors and oncogenes are commonly associated with reduced AMPK activity. In contrast, increased AMPK expression and activity were associated with improved survival across multiple tumor types in humans, suggesting that AMPK plays an important role in cancer.
AMPK may also exert antitumor activity through direct and indirect regulation of many important pathways that are essential for regulating cell growth and proliferation.
Cancer, which accounts for a quarter of human deaths, has always been the focus of scientific researchers. Aging is something that is relevant to each individual human being. AMPK plays an extremely important role in living organisms, which are based on cells.

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